Excellent ZL114A/5A06 joints by laser welding were obtained after parameter optimization. The microstructure,tensile strength and tensile fracture were analyzed by means of optical microscopy(OM), tensile testingmachine,high temperature fatigue testing machine,scanning electron microscopy( SEM) and energy dispersive Xrayspectrometry(EDX). The results show that the microstructure of the central welding zone is equiaxed crystal. The average tensile strength of untreated welding joints can reach 265 MPa,which is more than eighty percent of that of basemetal,excellent fatigue resistance of the joints is also demonstrated. The fracture appears near the fusion line ofZL114A,and under the premise of full weld penetration,the lower laser power, the smaller crystal size and the highertensile strength. Aluminum alloy conduithead with stressedskin construction was successfully welded and can meetthe requirements.