The welding crafts of 2195 aluminum-lithium alloy was investigated to solve the problems of high crack sensitivity， high porosity sensitivity， oxidation during welding of 2195 aluminum-lithium alloy. The crack sensitivity，mechanical properties and microstructure of the weld joints were analyzed. The results show that the increasing Cu content in fusion can effectively reduce the crack sensitivity of the weld joints， with K₁=0% and K₂=0%. The two pass welded joint display the best tensile properties. The tensile strength of joint is 376 MPa， while the elongation of joint is 5.5%. The problem of high porosity sensitivity is solved by increasing the cleaning depth of the welding plate.Using pure Ar gas for backward gas and root side purge gas can avoid the fusion welding from oxidation. The research of welding process provided technical support for the engineering application of 2195 aluminum-lithium alloy.