The cutting performance comparison was carried out when milling in-suit TiB_w/TiC_p reinforced titanium matrix composites at the cutting speed of 60 to 200 m/min. The results are verified on the skeleton part of the same material. The results show that the cutting speed is a factor affecting the milling temperature. When the cutting speed is in the range of 60 to 200 m/min， the milling temperature of titanium matrix composites increases with cutting speed increasing. The influence of cutting speed on milling temperature is greater than that of radial cutting width， and the influence of cutting speed and radial cutting width on surface quality is small. Based on the optimized parameters and the structural of skeleton parts， the process parameters of skeleton parts are determined， the milling parameters of rough machining are V=39.25 m/min， f_z=0.08 mm/z， a_e=12 mm， a_p=2 mm， and the milling parameters of finish machining are V=62.8 m/min， f_z=0.04 mm/z， a_e=10 mm， a_p=1 mm. Finally， the machining process optimization is verified to be reasonable and flexible.