The CFRP/Ti laminate structure is prone to delamination， tearing， burns， hole exit burrs and other hole making defects during the integrated driling process.Based on low-frequency vibration assisted drilling technology， after the second optimization， the optimal processing parameters are obtained in this article. Experimental results show：the hole-making quality is better under these two sets of processing parameters of speed of 400 r/min， feed of 12 mm/min， amplitude of 75 μm and speed of 500 r/min， feed of 21 mm/min， and amplitude 75 μm. Using high speed and large feed can improve processing efficiency.