In this paper, the simulation research about deformation after dual laser-beam bilateral synchronous welding (DLBSW) for the frame-truss tank wall structure is conducted. Firstly, the finite element model of DLBSW for the frame-truss tank wall structure is established,and verified by experimental results. Subsequently, the effect of welding sequence and direction on the deformation of frame-truss tank wall structure fabricated by DLBSW is emphatically investigated to obtain the deformation control strategy. Finally, the frame-truss tank wall structure is successfully manufactured by DLBSW with the optimized scheme. The results show that the welding deformation is greatly reduced under the welding sequence of "cross center welding". Based on the optimized welding sequence, the welding deformation can be further reduced by changing the welding direction of the middle three welds.