In order to study the environmental adaptability of nylon in long-life in-orbit spacecraft， space environmental adaptability evaluation indexes of nylon in space environment were proposed， and space environmental adaptability evaluation tests were designed and implemented.The test results show that the nylon shows friendly environmental adaptability in combustion heat， escaping harmful gases， vacuum mass loss and condensable volatiles， antibacterial and mildew resistance， tolerance to alternating temperature， and ionizing radiation. The fracture strength of nylon decreases significantly when subjected to atomic oxygen and ultraviolet radiation in space environment， and the synergistic effect of atomic oxygen and ultraviolet irradiation has a strengthening effect on the mechanical property damage of nylon. The nylon could be used as a material for long-term use in the space cabin environment， When used in the extravestrated environment， special consideration should be given to its mechanical properties under the influence of atomic oxygen and ultraviolet radiation.