The Material features and the machinability of PEEK/CA450 were analysed in this paper. The typical thin-wall parts technics characteristics, cutting parameters, and the heat treatment process of this material were studied. Then the optimum technological parameters were decided. The experiment results show three points. First, optimization of parts structure can decrease the internal stress and machining difficulty. Second the PCA tool and proper cutting parameters can ensure the machining quality of the thin-wall parts. Third the heat treatment in the machining process can improve parts finished rates and dimension accuracy. The PEEK/CA450 thin-wall parts that qualified complex design performance requirements is machined by the optimized machining process.