In order to obtain high-performance bearing bracket for spacecraft, the mechanical properties of short glass fiber reinforced polyether ketone (SGF/PEEK) with different fiberglass content were analyzed.And the injection mold and injection process parameters were optimized by the software of Moldflow. The results show that the mechanical properties of 30wt% SGF/PEEK are optimal. The mold flow simulation can predict the injection process effectively. Improving the sizes of main and secondary runners can effectively enhance the effect of pressure holding. The holding pressure and the mold temperature have remarkable influences on the warpage deformation of bearing brackets. The brackets formed by optimized process parameters have been applied to spacecraft fuel tanks successfully and passed the flight assessment.