The mechanical performances of honeycomb sandwich structure and M5 inserts were tested. Results were discussed and the effects of panel thickness, areal density of adhesive and bonding strength on the mechanical performances were analyzed. It was found that properly increasing the panel thickness was effective to improve the mechanical performances of honeycomb sandwich structure and inserts. On conditions of the same bonding strength, mechanical performance was not affected by areal density of adhesive, therefore adhesive with lower areal density should be chosen to reduce weight. The in-plane shear carrying load capacity of inserts was better than the normal pull-out load carrying capacity. While under in-plane shear load, the failure mode of inserts was panel failure. While under normal pull-out load, the failure mode of inserts was honeycomb instability failure which finally caused panel deformed and destroyed at last. The conclusions can be used in product design.