In order to study the welding mechanical properties of titanium alloy TA15 fabricated by laser melting deposition manufacturing, the specimen of welding joints were welded using electron beam and laser beam to obtain the welding mechanical properties, microstructure and microhardness by metallographic test, hardness test etc.. The results show that the highest tensile strength of two different welding ways can reach 953 MPa and the welding coefficient is greater than 0.9. Furthermore, the microstructure is mainly α' basket-weave martensite structures; and the heat affected zone is consisted of α phase and an acicular structure. Finally, titanium alloy TC4 fabricated by laser melting deposition manufacturing performs similar welding characteristics with that by traditional manufacturing.