Using carbide twist drills,the influence of machining parameters on cutting force, cutting temperature and hole quality of titanium alloy have been analyzed. The results show that with the increase of speed, axial force of the titanium alloy layer decreases gradually, and with the increase of feed,the specific value axial force of CFRP/titanium alloy layer ratio increase gradually.The exponential formula models of drilling force were obtained through regression analysis method and the regulation of the drilling force influenced by the feed and cutting speed was obtained respectively,F_z=2 088n^-0.1222·f_r^0.2016. The error of the two equations have been tested both less than 10%. When the feed is constant on titanium alloy layer, with the increase of speed on titanium alloy layer, the maximum discoloration ring diameter and the highest interpass temperature of CFRP increased gradually.