During in-orbit operation, the optical and thermal control performances of satellite thermal control coating will degrade due to integrated space environment effects and hence has a great impact on reliability and lifetime of satellites.In this paper, an in-orbit experiment of thermal control coatings is carried out for 5 years to investigate the influence of multi-factors environment. And the sensitive factor of coating performance is achieved and then the in-orbit property evolution law and life prediction model are built.Meanwhile, a ground simulation experiment with proton, electron and ultraviolet irradiation factors is carried out to study the influence of those factors on thermal control coatings.The results demonstrate that the absorptance of thermal coatings increase from 0.12 to 0.23 after 5-years' in-orbit operation while this value increases to 0.22 after the ground simulation test with the equivalent radiation dose.The thermal control performance degradation and test time or irradiation dose are linear related and positive correlated both in orbit and on ground, which has also verified the effectiveness of ground test.