There is a large superiority in digitalize manufacturing of large subassembly of frame kind. In this paper the method of application of MBD technology to subassembly of frame kind digital manufacturing is discussed. Digital coordination line of subassembly of frame kind and designing method of digital master tooling and its applying method on MBD environment is provided. It has important practical meaning in improving our subassembly of frame kind manufacturing technology and shorting its manufacturing cycle.