PA/ VMPET/ Al/ PE film of vaccum insulation panel is a kind of multilayer laminate envelope, which is one of the most candidates evelope materials. In this paper, the effect of heat-sealing temperature, heat-sealing time and heat-sealing pressure on the heat-sealing strength were investigated. Simultaneously, the process parameters of heat-sealing film was optimized using m-atlab software. Thermal analysis of PA/ VMPET/ Al/ PE was carried out by using differential scanning calorimeter etry (DSC). The results showed that the effect of heat-sealing temperature on heat-sealing strength was the most significant in the three parameters. The heat-sealing strength presented good at heat sealing temperature, heat sealing time and heat sealing pressure of 160 to 170℃, 1. 0 to 2. 0 s, 0. 2 to 0. 4 MPa, respectively. The optimal process parameters were simulated by Matlab software, heat-sealing temperature, heat-sealing time and heat-sealing pressure were 167℃, 1. 80 s and 0. 34 MPa, respectively. The result shows that the optimal process parameters were consistent with experimental values.