The problems which include difficulty in assembly, joint quality control, large distortion after welding exist in assembly welding process of heavy-thickness aluminum rectangle chassis. The corresponding fixture types were chosen for different type of structure plates. According to the characteristic of chassis type bodies deformation after welding, a fixture for the chassis was designed. Based on these works, electron beam welding is successfully used in the chassis assembly welding process. The chassis after welding meet the specifications of design requirement. The results show that the designed fixture and process is practical, and this research is advantageously used in solving these problems