In response to the high sensitivity of joint cracks and poor mechanical properties of T8 2195 Al-Li alloy during argon arc welding, the development of 2195 Al-Li alloy welding wire was carried out, and the microstructure, crack resistance, and comprehensive mechanical properties of the joint were studied. The results indicate that the 2195 Al-Li alloy fusion welding joint is mainly composed of α-Al, Al2Cu and Al3(Ti,Zr) phases, it has excellent crack resistance and mechanical properties.Its crack sensitivity K1 is less than 1%, K2 is 0%, and the tensile strength of the joint at room temperature is about 390 MPa,and elongation is 6.3%. The development of BJ-4505 welding wire provides technical support for the engineering application of 2195 Al-Li alloy.