Exit damages frequently occur during the drlling of titanium alloy， and the drilling quality is directly influenced by the axial force of drilling. This paper develops an analytical model to predict the axial drilling force of Ti6Al4V titanium alloy and conducts experiments to validate this model. The accuracy of prediction model is verified by experimental data， and the effects of cutting parameters on both the axial force and drilling quality are investigated. The results show that the maximum error between the predicted and experimental value of axial force is 12.8%. The predicted axial force values show good consistency with the experimental results，demonstrating that the model can effectively predict the drilling axial force for titanium alloys.The axial force and hole exit burr height decrease as spindle speed increases at a constant feed rate. The axial force increases with rising feed rate at a constant spindle speed， but the hole exit burr height decreases at first then increases. Except for the impact of drilling temperature at low feed rates， the hole exit burr height has a positive correlation with the axial force. The surface of hole exit is not burned and the burr height is relatively small under a spindle speed of 1000 r/min and a feed rate of 40 mm/min. And the better drilling quality is obtained.