In order to solve the problem that bubbles are easy to occur when the sensor products are filled with silicone gel，and improve the filling efficiency and quality of the sensor on the rocket， this paper adopts the centrifugal defoaming technology to study the defoaming method of silicone gel， and adopts the design method of two-factor optimization test to determine the optimal range of centrifugal defoaming parameters. After repeated tests， the optimal centrifugal defoaming process parameters were obtained， and the defoaming and curing effects were checked. The results show that 740r/min and 12min are the best centrifugal defoaming parameters for defoaming. The minimum diameter of bubbles in the solidified glue section is about 24μm， and the maximum diameter is about 54μm， and bridge is found， the resistance is greater than 200MΩ， no conduction short circuit， in line with NASA standards and no on-off short circuit between two adjacent bubbles. Through the batch production and test verification，the centrifugal defoaming process is ideal，stable， effective and feasible，for batch producion which meet the requirements of sensor products on the rocket.