The pyrolysis and combustion characteristics of Airbus 320 cargo hold liner (fiberglass/phenolic resin) and 3240 fiberglass board-FR4 (fiberglass/epoxy resin) were analyzed and compared by thermal gravimetric analyzer and cone calorimeter under the same conditions. The results show that the pyrolysis of Airbus 320 cargo hold liner and 3240 fiberglass board-FR4 can be divided into four and three stages, and the initial thermal decomposition temperature, ignition time and combustion duration of the cargo hold liner are all less than that of 3240 fiberglass board-FR4. The smoke time, release smoke rate (RSR) and total smoke release (TSR) of 3240 fiberglass board-FR4 are higher than the cargo hold liner, and the release smoke rate (RSR) and total smoke release (TSR) are 2 and 3.45 times higher than the cargo hold liner. The heat release rate (HRR) and total heat release (THR) of 3240 fiberglass board-FR4 are greater than that of cargo hold liner, and the peak heat release rate (pk-HRR) and total heat release (THR) of 3240 fiberglass board-FR4 are 1.47 and 1.94 times of cargo hold liner. Therefore, the Airbus 320 cargo hold liner is less dangerous to human life and aircraft operation safety after a fire.