Based on the I-II mix-mode high cycle fatigue crack propagation tests of AA7075-T6 aluminum alloy under different loading angles， the equivalent stress intensity factor （SIF） amplitude of the mix-mode crack tips was calculated by using M-integral in FRANC3D. By processing the data with seven-point increasing polynomial， the growth rate curve of mix-mode crack tip was calculated. The mix-mode fatigue properties were analyzed and the path and fracture properties of mix-mode crack propagation were discussed. The result of the experiment shows the parameters of Paris formula of pure type I fatigue crack propagation rate curve in the stage of stable growth and proves that， the lifespan of the type I fatigue crack propagation is the longest， and the life of mix-mode fatigue crack propagation have suffered various degrees of reduction. The numerical analysis and experimental results of the cracking direction of the mix-mode fatigue crack are compatible with the theory， and the fracture of the mix-mode fatigue is characterized by brittle fracture.