In order to study the influence of fiber orientation on temperature field distribution and hole-wall quality of CFRP, theoretical analysis and ABAQUS simulation analysis of cutting forms at different fiber orientation angles are studied. Through the drilling temperature distribution test and simulation analysis of drilling temperature field for CFRP unidirectional plate, orthogonal plate and quasi-isotropic plate, it was found that, the direction of carbon fiber has a great influence on the distribution of drilling temperature field. By comparing the quality of the pore wall at different fiber orientation angles observed by electron microscopy and confocal microscopy, it was found that the quality of the pore wall at 0 degree, 45 degree and 90 degree was better than the quality of the pore wall at 135 degree.