The 2219C10S aluminium alloy is first subjected to self-reacting friction stir welding, followed by TIG welding in the direction perpendicular to the friction stir welding, and then the cross-weld joint is made. In this paper the microstructure and mechanical properties of the cross-welded joint and TIG joint are comparatively analyzed. The microstructural characteristics of the two kinds of joints present similarities and differences. The similarities are that the weld zone of the two kinds of joints are all composed of the column section by the direct helium arc welding and the bowl area by AC pulse argon arc welding. The differences are that both the parent metal zones respectively are the small isometric grains and rolling plate strip grains, and the heat affected zones are coarsening on the basis of the parent metal zone. Microhardness test results show that the micohardness distribution trend of the two kinds of joints is "W" type, and the microhardness distribution gradient of the TIG joints is greater than that of the cross joint which has a relatively narrower softened area. Tensile test results reveal that two types of joints are broken in the heat affected zone. The tensile strength factor of the cross joint in the SR-FSW direction is 66.14% which is slightly lower than the TIG joints, while the elongation rate of the former is about 30% higher than that of the latter. The fracture surface of the cross joint is typically ductile fracture, and the TIG joint has some brittle fracture characteristics besides the ductile fracture characteristics.