The drilling process of CFRP and CFRP/Titanium stacks under various processing parmeters with twist drill was studied. And the process of drilling was simulated by using the finite element software Abaqus of 3d simulation module.Comparing critical thrust force and drilling hole quality of the simulation and test result, it shows that choose reasonable processing parameters under the premise of ensuring the quality of the hole, the optimum conclusions about processing parameters of drilling stacks materials can be obtained.