Existing image quality evaluation methods mainly focused on noise， clarity and other indicators，and lacked the comprehensive evaluation of the quality of the areas of concern in the weld region，defect region and image quality indicators region in the digitised image of the radiographic negative.To address the above problems，a comprehensive radiographic image quality evaluation technique that integrated multi-region quality features was proposed.Firstly， a set of evaluation index system covering multiple regions such as image quality indicators，weld seam and defects was constructed by combining the quality evaluation needs in the field of non-destructive testing；then，a comprehensive radiographic image quality evaluation method including the number of image quality indicators，clarity，contrast，information entropy and average greyness was proposed on the basis of hierarchical analysis method.The experimental results show that the proposed method can achieve the comprehensive evaluation of the digital image quality of the X-ray negative，which can quantitatively evaluate the overall image quality and also ensure the good quality of the image in the concerned area.