The elastic modulus and hardness of T800SC carbon fiber with different orientation respect to its axis direction were tested by nanoindentation, and the scatter in the data was treated in terms of the two-parameter Weibull statistical analysis. It is shown that with the increase of the intersection angle between the test plane and the axis direction, the elastic modulus and hardness of T800SC increase. When the intersection angle increases from 0° to 90°, the elastic modulus of T800SC rises to (50.96±5.73) GPa from (5.84±2.00) GPa, and the hardness increases from (2.71±0.51) GPa to (5.24±0.91) GPa. For the elastic modulus and hardness of T800SC carbon fiber with different orientation, the modulus of Weibull distribution ranges from 9.0 to 10.5 and from 6.0 to 8.0, respectively.